UTERINE TRANSPLANT – A PAGE FROM SCI FI.

The transplant medicine is not new – we have heard of kidney and liver transplant as common procedures. However, I was excited by the report of a successful pregnancy following a uterine (womb) transplant.

A uterine transplant is the surgical procedure whereby a healthy womb from a donor is transplanted to a recipient who was born without a womb or had womb removed in cancer surgery.

The uterus allow a normal reproduction process whereby the fertiled egg implant and grow into a fetus. This uterine transplant is a potential treatment for women with no uterus.

The first successful uterine transplant was performed in Turkey in 2011 for a women who had been born without the uterus. She managed to conceive in 2013 but had a miscarriage at 8 week gestation.

This success was followed by a more ambitious project undertaken by Professor Brannstrom and team at the University of Gothenburg, Sweden. The team performed uterine transplant on nine women. Only seven of them proceeded to embryo transfer following an IVF treatment. In 2014, they reported the first livebirth from a uterine transplant recipient, by caesarean section at 32 weeks. The baby weighed 1.7kg at birth.

The transplanted uterus is intended to be temporary and will be removed once successful pregnancies are completed. This is to avoid the need for long term immunosuppressant treatment. Immunosuppresant drugs are used in transplant medicine to avoiud graft rejection.

Currently this procedure remains experimental and is expensive. However, this successful pregnancy outcome is yet another major medical milestone in reproductive medicine.

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Author: Dr Ng Soon Pheng

Dr. Ng Soon Pheng MD(USM), M.Med (O&G), Fellow Reprod Medicine (Singapore), AM (Mal) Dr. Ng Soon Pheng qualified from University Kebangsaan Malaysia (UKM), Malaysia. After obtaining his post graduate degree, Dr. Ng Soon Pheng continued his clinical fellowship training in the field of IVF in Singapore. He was also the recipient of Yayasan Sultan Iskandar (Johor) Scholarship for the fellowship stint. Dr. Ng Soon Pheng has more than 10 years of working experience in the field of Obstetrics and Gynaecology in the public and university hospital, with special interests in infertility. He was an Associate Professor with the Department of O&G in Universiti Kebangsaan Malaysia (UKM) specialising in infertility. Dr. Ng Soon Pheng is currently Consultant Obstetrician and Gynaecologist with special interests in infertility at Columbia Asia Hospital - Puchong.